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Nicholas H Hunt Selected Research

Cerebral Malaria

1/2021Efficient Treatment of Experimental Cerebral Malaria by an Artemisone-SMEDDS System: Impact of Application Route and Dosing Frequency.
1/2017Controlled release of artemisone for the treatment of experimental cerebral malaria.
2/2016Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria.
12/2015Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites.
4/2015IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.
8/2014Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.
1/2014Cerebral malaria: gamma-interferon redux.
1/2013Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.
12/2012FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry.
1/2012Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria.
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Nicholas H Hunt Research Topics

Disease

25Cerebral Malaria
01/2021 - 09/2003
20Malaria
01/2019 - 03/2002
18Infections
11/2019 - 06/2002
8Inflammation (Inflammations)
10/2017 - 02/2005
6Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis)
11/2019 - 11/2012
5Hypoxia (Hypoxemia)
02/2016 - 03/2004
4Body Weight (Weight, Body)
07/2015 - 12/2008
4Colitis
11/2011 - 11/2007
3Hemorrhage
12/2015 - 12/2008
3Asthma (Bronchial Asthma)
09/2008 - 04/2004
3Necrosis
01/2007 - 09/2003
2Meningitis
08/2014 - 08/2014
2Neoplasms (Cancer)
12/2012 - 07/2006
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2011 - 12/2008
2Hyperplasia
09/2008 - 02/2005
1Type 2 Diabetes Mellitus (MODY)
10/2017
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2017
1Toxoplasmosis
01/2017
1Parasitic Diseases (Parasitic Disease)
01/2017
1Mental Disorders (Mental Disorder)
10/2016
1Obesity
07/2015
1Pneumococcal Infections
08/2014
1Brain Injuries (Brain Injury)
08/2014
1Ischemia
12/2012
1Dehydration (Water Stress)
12/2012
1Motor Neuron Disease (Primary Lateral Sclerosis)
12/2012
1Brain Diseases (Brain Disorder)
12/2012
1Herpes Zoster
01/2012
1Atherosclerosis
12/2011
1Brain Edema (Cerebral Edema)
08/2011
1Acute malaria
06/2011
1Hypotension (Low Blood Pressure)
03/2010
1Endotoxemia
03/2010
1Birth Weight (Birth Weights)
03/2008

Drug/Important Bio-Agent (IBA)

14CytokinesIBA
07/2017 - 09/2003
11Interferon-gamma (Interferon, gamma)IBA
02/2016 - 09/2003
9KynurenineIBA
01/2017 - 03/2002
7Lymphotoxin-alpha (Lymphotoxin)IBA
02/2016 - 09/2003
6InterferonsIBA
11/2019 - 05/2008
6Tryptophan (L-Tryptophan)FDA Link
10/2016 - 09/2003
4Antimalarials (Antimalarial Agents)IBA
01/2019 - 01/2012
4Proteins (Proteins, Gene)FDA Link
12/2015 - 01/2007
4EnzymesIBA
08/2014 - 02/2004
4Messenger RNA (mRNA)IBA
01/2012 - 06/2002
4Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
12/2011 - 06/2002
3artemisoneIBA
01/2021 - 08/2014
3AntigensIBA
04/2015 - 05/2006
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2007 - 03/2004
2Quinolinic AcidIBA
10/2017 - 05/2006
2piperaquineIBA
08/2014 - 01/2012
2Dextrans (Dextran)FDA Link
11/2011 - 08/2008
24- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
11/2011 - 07/2006
2SodiumIBA
11/2011 - 08/2008
2ChemokinesIBA
01/2008 - 11/2007
2Heme (Haem)IBA
06/2007 - 05/2006
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
05/2006 - 02/2004
2Lactic Acid (Lactate)FDA LinkGeneric
03/2004 - 03/2002
1Toll-Like Receptors (Toll-Like Receptor)IBA
11/2019
1Biological ProductsIBA
01/2019
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2017
1PolymersIBA
01/2017
1Amino AcidsFDA Link
10/2016
1Chemokine CXCL10IBA
02/2016
1Nitric Oxide (Nitrogen Monoxide)FDA Link
02/2016
1IronIBA
12/2015
1Fish OilsIBA
07/2015
1Dietary Fats (Dietary Fat)IBA
07/2015
1resolvin D1IBA
07/2015
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
07/2015
1Ceftriaxone (Ceftriaxon)FDA LinkGeneric
08/2014
1Mefloquine (Lariam)FDA LinkGeneric
08/2014
1Anti-Bacterial Agents (Antibiotics)IBA
08/2014
1Chloroquine (Aralen)FDA LinkGeneric
08/2014
1PhosphatidylserinesIBA
03/2014
1Dexfenfluramine (Redux)IBA
01/2014
1Phosphocreatine (Neoton)IBA
12/2012
1Oxygen (Dioxygen)IBA
12/2012
1CreatineIBA
12/2012
1Phosphates (Orthophosphate)IBA
12/2012
1InflammasomesIBA
11/2012
1Drug CombinationsIBA
01/2012
1LipidsIBA
12/2011
1Probucol (Lorelco)FDA Link
12/2011
1Heme Oxygenase-1IBA
12/2011
1Lipoproteins (Lipoprotein)IBA
12/2011
1BilirubinIBA
12/2011
1AntioxidantsIBA
12/2011
1Tocopherols (Tocopherol)IBA
12/2011
1ubiquinolIBA
12/2011
1Aquaporin 4IBA
08/2011
1MicroRNAs (MicroRNA)IBA
06/2011
1Epithelial Sodium ChannelsIBA
01/2011
1Endothelium-Dependent Relaxing Factors (Endothelium Derived Relaxing Factor)IBA
03/2010
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
12/2008
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
09/2008
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
09/2008
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
07/2008

Therapy/Procedure

1Injections
01/2021
1Airway Management
09/2008
1Lasers (Laser)
03/2008